Circle of Innovation Bronchopulmonary dysplasia (BPD) + Bronchopulmonary dysplasia (BPD) is the most common complication in premature babies. + Research into the development of the lungs generates new options for intervention and prevention. + To stimulate regeneration (self-healing) of the lungs, we need a fundamental understanding of lung function. + BPD is partly caused by inflammations around birth and the harmful effects of oxygen therapy. Maastricht UMC+ Circle of Innovation® PREVENTION AND TREATMENT OF BPD + The lungs of premature babies are not fully developed and need ventilator support. + Fragile lung tissue can be damaged by high oxygen levels and high pressures, leading to BPD. + Newborns with BPD show rapid breathing and are often dyspnoeic. They may develop COPD at a later age. + Maastricht UMC+ spearheads research into the association between BPD and COPD. HOW DO THE LUNGS DEVELOP BEFORE AND AFTER BIRTH? Generating knowledge PREVENT COPD AND GIVE NEWBORN BABIES A HEALTHY START ACCELERATING LUNG DEVELOPMENT + The number of babies born prematurely is rising, + Using the results from our research, we stimulate fortunately the survival rates have increased over lung development or protect the lungs before and the past decades. after birth. + Premature birth is often accompanied by the + We are examining applications of a combination of development of BPD. antioxidants and growth factors to prevent BPD. + Prevention increases survival rates and quality of life + We use preclinical models to accelerate the and reduces the incidence of COPD in later life. development of treatments. + Collaborating with pharmaceutical companies, we create additional + Recognition from the European Medicines resources for more and high-quality research into BPD, as well as more Agency has improved our collaboration with the employment. pharmaceutical industry. Healthy living Creating value Innovating healthcare
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