Chapter 4 2.5 AD MCI 2 C Gain %/% 1.5 1 0.5 0 0 0.1 0.2 0.3 0.4 0.5 Frequency Hz Figure 2 Group average gain spectrum for AD (solid), MCI (dashed) and C (dash- dotted). dCA linear transfer function results Table 2 shows a summary of dCA parameters. Figure 2 shows the group averaged gain and figure 3 the group averaged phase plots. None of the dCA parameters showed significant differences between the groups. Also all other parameters including the dCA parameters in the specific frequency bands used by Claassenet al 4, did not reveal significant group differences. Table 3 Windkessel model parameters of subjects with AD, MCI and controls AD (n=15) MCI (n=19) C (n=20) Ra 5.6 (0.7) 4.9 (0.4) 5.2 (0.5) NS mmHgs/ml 2-10 2-9 0-11 Rp 36 (3) 29 (2) 26 (2) AD-C mmHgs/ml 21-59 16-52 14-48 p=0.004 Cp 0.24 (0.02) 0.25 (0.02) 0.29 (0.04) NS ml/mmHg .12-.44 .13-.47 .13-.98 Fit error $fit 2.1 (0.5) 1.3 (0.3) 1.7 (0.5) NS 0.4-7 0.04-5 .3-10 All data are presented as mean (SEM) min max. n=number of subjects, p-values of multifactor Anova with Sidak correction 68
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