l DW. Comparison of static surements.Stroke26: 1014- Chapter 4 YC, Binsted G, Jones LW, KJ, Smirl JD, Day TA, Lucas scranial Doppler ultrasoundsingle value difference. The fit error was calculated as the sum of squares of the error function components as expressed in equation 3. 1917 g fit ? -g k 2 (3) k ?1 Table 1 General characteristics of subjects with AD, MCI and controls. MMSE =mini mental state evaluation, MTA = medial temporal lobe atrophy, sBP, dBP, mBP = systolic, diastolic, mean blood pressure, mCBFV = mean cerebral blood flow velocity, CVRi = cerebrovascular resistivity index AD (n=15) MCI (n=19) C (n=20) Male/female 8/7 11/8 10/10 NS 72 (2) 70 (2) 70 (1) Age year NS 58-87 58-80 59-78 Level of Education % Lower 53 37 45 NS Middle 33 16 35 NS Higher 13 47 20 NS AD-MCI 19.8 (1.2) 27.6 (0.3) 29.0 (0.3) MMSE p<0.001 12-27 24-30 26-30 AD-C p<0.001 MTA > 2 % 80 33 no data p=0.011* End-tidal CO2 6.0 (0.4) 6.3 (0.2) 5.3 (0.1) MCI-C % p=0.006 134 (4) 133 (2) 133 (3) sBP mmHg NS 116-156 116-150 107-158 89 (2) 86 (2) 88 (2) dBP mmHg NS 78-101 70-105 61-104 104 (2) 101 (2) 103 (3) mBP mmHg NS 90-119 88-117 76-119 mCBFV 37.3 (2.3) 46.6 (2.8) 51.0 (2.8) AD-C cm/s 26-54 27-77 32-82 p=0.003 CVRi 2.9 (0.2) 2.3 (0.1) 2.1 (0.1) AD-C mmHgs/cm p=0.002 AD-MCI p=0.02 All data are presented as mean (SEM) min max. n=number of subjects, p-values of multifactor Anova with Sidak correction * p-value of Mann-Whitney test 66
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