Page 105

proefschrift gommer inhoud met kaft.indd

Assessment of dCA during CPB The TFA method for quantifying dCA is applicable only when sufficient variabil- ity in blood pressure subsequently is present leading to cerebral blood flow velocity variability. Because during CPB hardly any variation in ABP occurs, blood pressure variability could be induced by cyclic changes in pump flow. Diehlet al 14 showed in awake subjects that blood pressure variations can be induced by breathing at a paced rhythm of 6/min. Analogue to this we induced an indexed pump flow change from 2.0 to 2.8 l/min/m2 during CPB at a fre- quency of 6/min. The present study was performed to test the CBFV response to pump flow induced oscillations in ABP, and to evaluate cerebral autoregulation and cerebral carbon dioxide reactivity during normothermic CPB using nonpul- satile flow. 103


proefschrift gommer inhoud met kaft.indd
To see the actual publication please follow the link above