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Proefschrift binnenwerk Manon Ernst_DEF.indd

C H A P T E R   4     In   this   study,   we   analyze   the   growth   pattern,   expressed   as   BMI   and   weight   for   height  values  of  SGA  children,  treated  with  rhGH  and  compare  the  results  with  the   Deuterium   TBW   study14 to   evaluate   which   method   offers   the   highest   accuracy   in   estimating  the  change  in  body  composition  in  SGA  children  treated  with  rhGH.   Methods   Inclusion   Data  for  this  study  were  collected  at  the  department  of  Pediatrics  at  the  academic   hospital  of  Maastricht,  in  the  South  of  The  Netherlands.  Included  were  SGA  children   who   met   the   inclusion   criteria   reviewed   by   the   Dutch   Growth   Research   Founda-­‐ tion7:  Birth  length  or  weight:  <  -­‐2  standard  deviation  (SD)  for  gestational  age,  actual   height:   <   -­‐2.5   SD   and/or   deviating   >   1   SD   from   target   height   (TH),   age:   >   4   years,   bone   maturation:   ≤   13   years   in   girls   and   ≤   15   years   in   boys,   no   signs   of   catch-­‐up   growth  in  the  previous  year.     Exclusion   criteria   include:   Evident   dimorphism   suggestive   for   an   (un)known   syn-­‐ drome  or  chromosomal  anomaly,  skeletal  dysplasia  or  severe  disproportion,  severe   complications   after   birth   or   during   the   first   weeks   of   life   with   current   lung   prob-­‐ lems,  nutritional  deficiencies  or  malabsorption,  untreated  endocrinological  anoma-­‐ lies,  untreated  chronic  systemic  or  organ  diseases  or  use  of  medication  with  nega-­‐ tive  effect  on  growth,  suspicion  of  emotional  deprivation,  active  malignancy  or  se-­‐ vere  psychomotoric  retardation.   Measurements   Measurements   of   weight   and   height   were   taken   at   start   of   rhGH   treatment   and   1   year  thereafter  with  a  variance  of  1  month.       Height   was   measured   with   the   Harpenden   stadiometer,   weight   with   an   electronic   scale  with  digital  readings  accurate  to  5  gram.       BMI  was  calculated  as:         BMI =   weight푘푘푘푘 62     height푚푚!     The   values   of   weight,   height,   BMI   as   well   as   weight   for   height   were   expressed   in   terms  of  standard  deviation  scores  (SDS):      


Proefschrift binnenwerk Manon Ernst_DEF.indd
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