C H A N G E I N T O T A L B O D Y W A T E R A S A P R E D I C T I V E T O O L F O R G R O W T H H O R M O N E T R E A T M E N T R E S P O N S E Conclusion In conclusion, changes in body composition data proved to be valuable for the dis-‐ tinction between adequate and inadequate responders to GH therapy. In GHD chil-‐ dren the adequate responders are distinguished by a change in TBW/height2 below 0.7 l/m2, in SGA children the adequate responders are distinguished by a change in TBW/height2 exceeding 0.7 l/m2. It should be realized that the cut off values for growth response as well as change in body composition are more or less arbitrary, although the findings in this study show that a change in body composition is an actual tool in further predicting the individual response on rhGH treatment. 53
Proefschrift binnenwerk Manon Ernst_DEF.indd
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