Table of Contents Chapter 1 General introduction and outline of the thesis 7 Chapter 2 Advanced intraoperative imaging methods for laparoscopic 17 anatomy navigation: an overview PART I NEAR‐INFRARED FLUORESCENCE‐GUIDED LAPAROSCOPY 35 Chapter 3 Fluorescence cholangiography during laparoscopic cholecystectomy: 37 a feasibility study on early biliary tract delineation Chapter 4 Combined vascular and biliary fluorescence imaging in 51 laparoscopic cholecystectomy Chapter 5 Near‐infrared fluorescence laparoscopy of the cystic duct and 65 artery in pigs: performance of a preclinical dye Chapter 6 Application of a new dye for near‐infrared fluorescence laparoscopy 77 of the ureters: demonstration in a pig model PART II DIFFUSE REFLECTANCE SPECTROSCOPY DURING SURGERY 87 Chapter 7 Multispectral characterization of tissues encountered during 89 laparoscopic colorectal surgery Chapter 8 Automated spectroscopic tissue classification in colorectal surgery 107 Chapter 9 Differentiation between nerve and adipose tissue using wide‐band 127 (350 – 1830 nm) in vivo diffuse reflectance spectroscopy Chapter 10 Parathyroid differentiation during thyroid and parathyroid surgery 145 by spectroscopy (350 – 1830 nm) Chapter 11 Summary, discussion and future perspectives 165 Nederlandse samenvatting 181 Valorization addendum 191 List of publications 201 Awards 207 Dankwoord 211 Curriculum Vitae 217
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