Chapter 3 to‐background ratio (TBR). TBR was defined as the mean fluorescence intensity (FI) of two point regions of interest (ROIs) in the target (being CD or CBD) minus the mean fluorescence intensity of two background (BG) ROIs in the liver hilum, divided by the mean fluorescence intensity of the two background ROIs in the liver hilum; in formula: TBR = (FI of target – FI of BG) / FI of BG. Statistical analysis of time measurements A paired T‐test was applied for determination of possible significant differences between the time measurements from ‘introduction of laparoscope´ until ‘identification of CD / CBD’; comparing NIRFC with conventional imaging. Results Fifteen consecutive patients, scheduled to undergo an elective laparoscopic cholecystectomy, were included in this study (cholecystolithiasis 11, cholecystitis 4). Preoperatively, written informed consent was obtained from all patients. Four men and eleven women had a median age of 52 (27‐76) years and a median body mass index of 26.2 (19.7‐31.6) kg/m2. Preoperatively no signs of biliary tract obstruction were present. Patient characteristics are shown in Table 3.1. Table 3.1 Patient characteristics Number of subjects 15 Gender 4 male 42 11 female Age (years) 52 (27‐76) Body Mass Index (kg/m2) 26.2 (19.7‐31.6) Indication for operation 11 cholecystolithiasis 4 cholecystitis ICG dose 1ml (2.5mg/ml) Bile duct identification using fluorescence cholangiography The median time interval from preoperative ICG administration until first NIRFC view with the laparoscope was 33 (19–67) minutes. The time until first NIRFC depended mainly on whether an adhesiolysis had to be conducted before initial exposure of the liver hilum could be obtained. After start of surgery the common bile duct could be identified significantly earlier using NIRFC compared with WL imaging (median 22 and 32 minutes respectively; P‐value 0.001). Using NIRFC the cystic duct was delineated
proefschrift_Schols_SLV
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