Parathyroid differentiation during thyroid and parathyroid surgery by spectroscopy 153 Results In 19 patients (4 male, 15 female) undergoing parathyroid or thyroid surgery, 299 in vivo tissue spectra were recorded on 62 tissue sites (thyroid n=23, parathyroid gland n=21, adipose tissue n=18). Table 10.1 summarizes patient characteristics and the number of measured sites per tissue type. Figure 10.3 shows mean diffuse reflectance spectra and corresponding standard deviations for thyroid, parathyroid and surrounding adipose tissue. Table 10.1 Study subject characteristics and measured sites per tissue type Subject Gender Age BMI Indication for surgery Surgical procedure Sites per tissue type Thyroid Parathyroid Adipose 1 M 67 24 Bethesda 3* node thyroid left Left HT 2 2 0 2 F 55 32 PH Right PAR 2 1 2 3 M 54 31 MEN‐2a syndrome, medullar thyroid carcinoma left TT + radical LND neck, right axillary LND 0 0 1 4 F 14 21 PH Left PAR 2 2 2 5 F 67 37 Status after hemithyroidectomy right, in which a follicular carcinoma was found Resection of remaining thyroid (left HT) 0 2 1 6 F 53 34 Multinodular goiter TT 2 2 1 7 F 56 44 Bethesda 2* node thyroid right Right HT 0 0 1 8 F 67 30 Multinodular goiter Left HT 1 0 0 9 F 60 43 Tertiary hyperparathyroidism after kidney transplantation Subtotal parathyroid resection 1 1 0 10 F 55 ‐ Multinodular goiter Left HT + subtotal right thyroidectomy 1 0 0 11 F 50 18 Multinodular goiter Left HT 1 1 1 12 M 80 26 PH Left PAR 1 0 1 13 F 54 35 PH Right PAR 1 1 1 14 M 74 29 PH Right PAR 1 0 1 15 F 60 31 Multinodular goiter Left HT 1 1 1 16 F 46 30 Multinodular goiter Left HT 1 2 1 17 F 53 34 Bethesda 3* node thyroid right Right HT 2 2 2 18 F 23 23 Graves’ disease TT 2 2 1 19 F 49 19 Multinodular goiter Left HT 2 2 1 Sites per tissue type (grand total 62) 23 21 18 Spectra per tissue type (grand total 299) 112 97 90 * The Bethesda system was used for reporting thyroid cytopathology34. M = male; F = female; BMI = body mass index; PH = primary hyperparathyroidism; PAR = parathyroid adenoma resection; HT = hemithyroidectomy; TT = total thyroidectomy; LND = lymph node dissection.
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