Parathyroid differentiation during thyroid and parathyroid surgery by spectroscopy Figure 10.1 shows the fibre probe tip composed of eight optical fibres: One central receiving fibre (400 um diameter, NA 0.22 ±0.02) and seven illuminating fibres (300 um diameter, NA 0.22 ±0.02). The rigid stainless steel probe tip has a 2 mm diameter and a length of 10 mm. The remaining length of the sterile fibre probe is highly flexible. Figure 10.1 Intraoperative fibre probe tissue measurement Intraoperative spectral fibre probe measurement performed during a left hemithyroidectomy procedure. The sterile optical fibre probe is gently brought into contact with one of the parathyroid glands. Right lower corner: close‐up of the fiber probe tip. A ring light of seven fibers (illuminated white) injects light into the tissue, one central fiber (here for illustration purposes illuminated yellow) transports the diffusely reflected light to the spectrometer. In vivo data acquisition During parathyroid and thyroid resections, in vivo wide‐band diffuse reflectance spectra (350‐1830 nm, 1 nm spectral resolution) were collected. For each tissue type, five spectra per site (taking 30 seconds per site) were acquired, covering at least one site 149
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