Multispectral characterization of tissues encountered during laparoscopic colorectal surgery The depth penetration at different wavelengths and the in‐depth tissue characterization, e.g. beneath a layer of fatty tissue. This is highly relevant as many tissue structures in patients are (partly) covered by others. Influence of perfusion and oxygenation. These aspects vary between the in vivo and ex vivo situation16,17 and need to be identified with respect to spectral analysis. Modeling the influence of these parameters will raise insights above the empirical, ‘black box’ level. Hence, future research should repeat these measurements in vivo. The presented results offer motivation for such future research. 101 Conclusion Spectral differentiation of blood vessels, mesenteric adipose tissue, colonic tissue, tumorous tissue inside the colon, and ureter is feasible in freshly explanted human colonic specimen using ex vivo spectral analysis without the addition of a contrast agent. In future research the results and insights from this study may be applied for the design of dedicated spectral imaging instruments to enhance in vivo visual contrasts of the investigated essential structures with respect to surrounding tissues and ultimately help prevent intraoperative iatrogenic injury.
proefschrift_Schols_SLV
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