Cerebral autoregulation in AD and MCI prognostic factors for developing AD. CVRi shows to be an easy to determine parameter and could be of value in the multidimensional diagnosis of AD. Linear transfer analysis of cerebral autoregulation may be used as a tool to char- acterise the cerebrovascular dynamics in AD and particularly in MCI patients, but probably the control of cerebral blood flow needs to be more strongly pro- voked by inducing greater blood pressure variability. Regarding the latter, future studies should evaluate the predictive power of such measurements with regard to the development of MCI into AD. Acknowledgements Research supported by: Internationale Stichting Alzheimer Onderzoek (ISAO) grant # 06518 to JR. The authors thank Prof. R.B. Panerai (University of Leicester, UK) for his valu- able contributions to the manuscript. References 1. Association AP editor.Diagnostic and Statistical Manual of Mental Disor- ders. Washington, DC: American Psychiatric Association, 1994. 2. Bateman GA, Levi CR, Schofield P, Wang Y, and Lovett EC. Quantitative measurement of cerebral haemodynamics in early vascular dementia and Alzheimer's disease.J Clin Neurosc13: 563-568, 2006. 3. Blaber AP, Bondar RL, Stein F, Dunphy PT, Moradshahi P, Kassam MS, and Freeman R. Transfer function analysis of cerebral autoregulation dynamics in autonomic failure patients.Stroke28: 1686-1692, 1997. 4. Claassen JA, Diaz-Arrastia R, Martin-Cook K, Levine BD, and Zhang R. Altered cerebral hemodynamics in early Alzheimer disease: a pilot study using transcranial Doppler.J Alzheimers Dis17: 621-629, 2009. 5. de la Torre JC. Vascular Basis of Alzheimer's Pathogenesis.Ann N Y Acad Sci977: 196-215, 2002. 6. Dickerson BC, and Sperling RA. Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alz- heimer's disease: Insights from functional MRI studies.Neuropsychologia 46: 1624-1635, 2008. 7. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, and Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol149: 351-356, 1987. 75
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