Chapter 3 Figure 2.Dynamic cerebral autoregulation phase angle in the low frequency range versus cerebrovascular reactivity before (g380 solid) and after (× dashed) acetazolamide infusion. The question can be raised whether cerebral autoregulation still is intact to a large extent, because the dose of ACZ was insufficient for maximal vasodilata- tion. The dose-response relationship of ACZ has been investigated both in ani- mal and human studies 5, 6, 21,11. From animal experiments, there is evidence that ACZ administration does evaluate only part of the autoregulatory capacity. In anesthetized rats it was shown that autoregulation was not exhausted after acetazolamide administration even at a dose of 21 mg/kg. In humans, Grossmann et al 11 showed that with 18 mg/kg a higher cerebrovascular reactivity was measured than with 13 mg/kg. Yet, based on the adverse effects, although re- 52
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