Page 52

proefschrift gommer inhoud met kaft.indd

Chapter 3 Figure 1.Group-averaged spectral phase plot before (solid) and after (dashed) acetazolamide infusion. Marked by the dashed boxes are the low frequency and high frequency ranges. Discussion Dynamic cerebral autoregulation In this study cerebral autoregulation parameters were studied in first-ever lacu- nar infarct patients. The phase angle in the low frequency range ( LF) is regarded to be the dominant and most relevant parameter to quantify dCA 23. Theoreti- cally, LF may range from –! to +! radians. In human, positive LFaround 0.9 indicates normal autoregulation. Before ACZ infusion, baseline dCA has a me- dian LF of 1.05 radians which is in the normal range as shown in control subjects by Reinhardet al 28(0.84 ± 0.26 rad) and Imminket al 13(1.0 ± 0.3 rad). As opposed to our findings, Immink and co-workers showed in the same study for lacunar infarct patients reduced LF (0.57 ± 0.3 rad). Two facts may explain the discrepancy between Immink’s findings and ours. First, in Immink’s study dCA was assessed within 72 hours in the acute post-infarct time span, whereas we performed our measurements between one and two months post-infarct. Second, in the post-infarct period all our patients were treated with statins, a medication 50


proefschrift gommer inhoud met kaft.indd
To see the actual publication please follow the link above