88 Chapter 5 Abstract Background and purpose: The International Subarachnoid Aneurysm Trial (ISAT) provided valuable data on patient outcome after endovascular coiling and surgical clipping of ruptured aneurysms. The purpose of this study was to retrospectively review the t1-year outcome (in terms of survival, independence, and rebleeding) of patients who were treated in a routine clinical setting Material and methods: Records of patients presenting with a subarachnoid hemorrhage (SAH) from a ruptured aneurysm between 2000 and 2008 were reviewed. The 403 patients who met the inclusion criteria harbored 443 treated aneurysms; 173 were managed surgically and 230 by endovascular means. Mean clinical follow-up was 33.9 months (range, 12-106 months). Results: The pretreatment clinical condition according to the Hunt and Hess grading scale (HH) was significantly better in the surgically treated patients (p=0.018). Death occurred in 11.6% after surgery and in 17.4% after endovascular treatment (p=0.104). Of the surviving patients in the surgical and endovascular groups, 80.3% and 87.2%, respectively, were able to live independently with grades 0–2 on the modified Rankin scale (mRS) (p=0.084). Complete aneurysm occlusion was achieved significantly more often after surgical treatment (p < 0.001). Rebleeding occurred in 3.1% and 2.3% of the patients after surgical treatment and endovascular coiling, respectively. The occurrence of a residual aneurysm at the end of a coiling procedure was significantly related to the frequency of rebleeding (p=0.007). Conclusion: The management of patients with intracranial aneurysms in a routine clinical setting shows good and comparable rates of mortality and independence. Coiling results in lower rates of complete aneurysm occlusion. Postcoiling angiography showing a residual aneurysm is a good predictor of the risk of rebleeding.
proefschrit Van Zwam inhoud met kaft en stellingen.indd
To see the actual publication please follow the link above