Late recanalization of adequately coiled intracranial aneurysms 119 cohort of whom the initial R&R occlusion status had been specified in the report. The OR with its 95% CI was calculated and the association was tested using a chi square test or Fisher exact if appropriate. In the 400 patients of the multicenter LOTUS study odds ratios (OR) with 95% CI were calculated for binary outcome measures: patient gender, rupture status of aneurysms, aneurysm size ш 10 mm, posterior circulation aneurysms and basilar tip aneurysms. Subsequently, risk factors with a P-value ч0.10 were included in a multivariate logistic regression model. A backward selection strategy was used and odds ratios with 95% CI were calculated. Results Baseline patient and aneurysm characteristics Sixty-two patients with 71 coiled aneurysms, treated between December 1997 and June 2005, were included. During this period, 202 intracranial aneurysms in 180 patients had been treated by coiling in the MUMC. Of 180 patients, 173 with 195 aneurysms had six months follow-up angiography and 150 (77%) aneurysms in 138 patients proved to be adequately occluded at this six month angiographic follow-up. Of 138 eligible patients with 150 aneurysms, 36 could not be included (1 patient with clipped aneurysm, 35 patients >70 yrs of age) and twenty-two patients were lost to follow-up (12%). We invited 80 patients to participate in the study, but 18 declined (participation grade 77.5%) (Figure 1). Comparison of patient- and aneurysm characteristics of the 62 patients from the MUMC with all patients included in the LOTUS multicenter study did not show any significant difference (Table 1). Table 1. Patient- and aneurysm characteristics of all participants in long-term MRA follow-up in the multicenter study (left column) and of MUMC patients in the present study (middle column). 400 patients/ 62 patients/ OR (95% CI), p 440 aneurysms 71 aneurysms with long-term of the MUMC MRA follow-up Women 276 (69%) 47 (76%) 1.41 (0.76-2.61), 0.28 Mean age (yrs) 54.5 54.7 - median, range 55, 23-70 56, 23-70 - Ruptured aneurysms 344 (78%) 60 (84%) 1.52 (0.77-3.01), 0.24 Mean size (mm) 6.5 6.1 - median, range 6.0, 2-20 5.0, 2-18 - Size ш10 mm 66 (15%) 8 (11%)* 0.72 (0.33-1.57), 0.41 Aneurysm location Anterior circulation 327 (74%) 54 (76%) - ACA 143 25 - MCA 44 3 - ICA 140 26 - Posterior circulation 113 (26%) 17 (24%) † 0.91 (0.51-1.64), 0.75 Basilar tip 61 10 † 1.02 (0.49-2.09), 0.96 MRA: Magnetic Resonance Angiography; OR: Odds Ratio; ACA: anterior cerebral artery; MCA: middle cerebral artery; ICA: internal carotid artery; - : not calculated.
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